The main objectives of our study were to prepare and evaluate a biodegradable nanoparticulate system of\r\nLetrozole (LTZ) intended for breast cancer therapy. LTZ loaded thiolated chitosan (TCS) nanoparticles were prepared\r\nby emulsion-solvent evaporation method. LTZ loaded TCS nanoaprticles were characterized by infrared spectra, drug\r\nentrapment efficiency and in vitro release. The system sustained release of LTZ significantly and further investigation\r\ncould exhibit its potential usefulness in breast cancer therapy. The nanoparticles of LTZ prepared from TCS - may\r\nrepresent a useful approach for targeting its release at its site of absorption, sustaining its release.
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